|Diseases/Research Topics |
Drug discovery, Integrins, Signal Transduction
My laboratory is interested in understanding the mechanisms by which signals are transmitted from cell surface receptors to the cytoplasm and nucleus.
Our efforts are focused on the role of lipid and protein phosphorylation and dephosphorylation in the regulation of signal transduction. In this regard, we are primarily interested in the regulation of signal transduction pathways in tumor cells as well as similar signaling events in myeloid and endothelial cells as they relate to the control of the tumor microenvironment. We would like to understand how the phosphorylation and dephosphorylation of cellular proteins and lipids results in regulated and coordinated signal relay.
Moreover, we are interested in how components of other signaling pathways (eg, PI-3 kinase, small G proteins, phosphatases, serine/threonine kinases, PLC protein kinase A, PKC, etc.) interact to fine tune and regulate cell signaling in the context of other environmental influences or when different receptors are activated at the same time.
As more and more information accumulates concerning the fundamental mechanisms controlling specific components of signal relay, perhaps we will be able to propose an integrated model of how cells respond to a complex array of external environmental conditions in a coordinated and controlled manner.
We are interested in converting target discovery and validation into drug discovery and drug development in particular as it relates to specific kinases and phosphatases and translating this basic science information from 'bench to bedside.”