Publications
Recent Peer-Reviewed Publications
300. Lee, S., Howell, S.B., Opella, S.J., NMR and mutagenesis of human
Copper Transporter 1 (hCtr1) show that Cys-189 is required for correct
folding and dimerization, Biochem Biophys Acta, 1768(12):3127-34. PMID:
18558714; PMCID: PMC2275670
301. Safaei R., Otani, S., Larson, B.J., Rasmussen, M.L., Howell, S.B.
Transport of Cisplatin by the Copper Efflux Transporter ATP7B. Mol Pharmacol,
73:461-468, 2008. PMID: 17978167
302. Kowalski, D. Pendyala L., Daignan-Fornier, B., Howell, S.B., Huang,
R.Y. Disregulation of Purine Nucleotide Biosynthesis Pathways Modulates
Cisplatin Cytotoxicity in Saccharomyces cerevisiae. Mol Pharmacol. 74:1092-100,
2008. PMID: 18612078
303. Safaei, R., Maktabi, M.H., Blair, B.G., Larson, C.A., Howell, S.B.,
Effects of the loss of Atox1 on the cellular pharmacology of cisplatin,
J Inorgan Biochemistry, 103:333-41, 2009. PMID: 19124158
304. Larson, C.A., Blair, B.G., Safaei, R., Howell, S.B. The Role of
the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-based
Drugs. Mol Pharmacol. 75:324-30, 2009. PMID: 18996970; PMCID: PMC2684896
305. Jandial, DD, Farshchi-Heydari, S, Larson, CA, Elliot, GI, Wrasidlo,
WJ, Howell, SB, Enhanced delivery of cisplatin to intraperitoneal ovarian
carcinomas mediated by the effects of bortezomib on the human copper transporter
1, Clin Cancer Res, 15:553-60, 2009. PMID: 19147760; PMCID: PMC2707998
306. Blair, B.G., Larson, C.A., Safaei,R., Howell, S.B., Copper Transporter
2 (CTR2) regulates the cellular accumulation and cytotoxicity of cisplatin
and carboplatin, Clin Cancer Res 15:4312-21, 2009. PMID: 19509135
307. Yuan, X., Lin, X., Manorek, G., Kanatani, I, Cheung, L.H., Rosenblum,
M.G., Howell, S.B., Recombinant CPE fused to TNF targets human ovarian
cancer cells expressing the claudin-3 and claudin-4 receptors, Mol Cancer
Ther, 7:1906-15, 2009. PMID: 19567823
308. Jandial, D.D., Farshchi-Heydari, S., Pu, M., Messer, K., Howell,
S.B., Tumor platinum concentration following intraperitoneal administration
of cisplatin versus carboplatin in an ovarian cancer model. Gynecol Oncol,
115:362-6, 2009. PMID: 19775736; PMCID: PMC2707998
309. Wang, X., Zhao, G., Van, S., Jiang, N., Yu, L., Vera, D., Howell,
S.B., Pharmacokinetics and tissue distribution of PGG-paclitaxel, a novel
macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460
lung cancer xenografts, Cancer Chemother Pharmacol. Cancer Chemother Pharmacol,
65:515-26, 2010. PMID: 19593566; PMCID: PMC2797414
310. Li, S.D., Howell, S.B., CD44-targeted microparticles for delivery
of cisplatin to peritoneal metastases, Mol Pharmacol 7:280-90, 2010. PMID:
19994852.
311. Feng, Z. Zhao, G., Yu, L., Gough, D., Howell, S.B. Preclinical efficacy
studies of a novel nanoparticle-based formulation of paclitaxel that out-performs
Abraxane, Cancer Chemother Pharmacol, 65:923-30, 2010. PMID: 19685054
312. Luca Beretta, G., Benedetti, V., Cossa, G., Assaraf, Y.G.A, Bram,
E., Gatti, L., Corna, E., Carenini, N., Colangelo, D., Howell, S.B., Zunino,
F., Perego, P., Increased levels and defective glycosylation of MRPs in
ovarian carcinoma cells resistant to oxaliplatin, Biochemical Pharmacol,
79:1108-1117, 2010. PMID: 20005867
313. Blair, B.G., Larson, C.A., Adams, P.L., Abada, P.B., Safaei, R.,
Howell, S.B., Regulation of CTR2 Expression by Copper and Cisplatin in
Human Ovarian Carcinoma Cells, Mol Pharmacol, in press, 2010 Mol Pharmacol.
2010 Mar 1. [Epub ahead of print] 314. Howell, S.B., Safaei, R., Larson,
C.A., and Michael Sailor, Copper transporters and the cellular pharmacology
of the platinum-containing cancer drugs, Mol Pharmacol, 2010 [Epub ahead
of print] PMID: 20159940